In addition, we identified three patients with other types of CHD (with and without extracardiac abnormalities) and a heterozygous missense variant in KDR (de novo in two patients and inherited in the third), and two patients with a de novo KDR variant (one missense and one PTV, both heterozygous) had a noncardiac phenotype (Supplementary table 10). Here, KDR is linked to coronary artery disorder.