Exome sequencing studies have provided robust evidence that dominant, mainly truncating, pathogenic variants in FLT4, encoding VEGF receptor 3 (VEGFR3), are an important genetic cause of TOF.8,9 Furthermore, a candidate gene study10 identified rare variants in other VEGF signaling genes, including KDR, which encodes VEGFR2.11 Yet the causal role of rare variants in this gene has not been definitively established for CHD. Here, FLT4 is linked to coronary artery disorder.