PALB2 and breast carcinoma: While PALB2 was identified as a cause of hereditary breast cancer in 2007,6 it is only more recently that PALB2 PGVs have been shown to be associated with a >50% lifetime breast cancer risk in females.7,8 Routine diagnostic testing of PALB2 has been offered in MCGM since 2016, with some samples having been analyzed previously through research studies with diagnostic laboratory confirmation of any PGVs identified.