PALB2 and breast carcinoma: Here, the TNT phenotype occurred in 12/43 (27.9%) PALB2 PGVs, as compared with 11.1% (204/1843) of all breast cancers cases known to our service where full histology was known (OR = 3.11, 95% CI = 1.61–5.96, P = 0.002).