The mean age at diagnosis of first breast cancer for those with a PALB2 PGV was 49.8 years (median 50 years, SEM = 2.30, range = 24–77 years) and, for the CHEK2_c.1100delCPGV, 49.3 years (median 49.3 years, SEM 1.83, range 27–76 years). Here, PALB2 is linked to breast cancer.