In HCC, a loss-of-function approach revealed several RAB10 downstream signaling pathways (such as InsR, Met/HGFR, c-Kit/SCFR, EphA3, EphB4, VEGFR2/KDR, Akt/PKB/Rac) that could be responsible for the regulation of cell survival. This evidence concerns the gene EPHB4 and hepatocellular carcinoma.