To study the role of Kv7.1 in insulin secretion and glucose homeostasis in greater detail, we developed a novel LQTS mouse model using clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 gene editing technique28 to insert the LQT1-causing LoF mutation Kcnq1-A340V. This evidence concerns the gene INS and familial long QT syndrome.