INPP5D and B-cell chronic lymphocytic leukemia: The analysis of mRNA expression levels of INPP5D, encoding the phosphatase SHIP1, revealed that all 210 CLL samples analyzed39 expressed SHIP1 mRNA, with higher levels in samples derived from CLL patients with mutated IgVH genes that have a favorable clinical prognosis as compared to those with an unmutated IgVH (Fig. 2a).