We then analyzed SHIP1 protein levels of primary CLL samples and compared them to B cells of healthy age-matched donors, both derived from the peripheral blood, and found significantly higher SHIP1 expression and phosphorylation levels in CLL than in normal peripheral B cells, which is potentially induced by the activated BCR status in CLL5 (Fig. 2b). Here, BCR is linked to B-cell chronic lymphocytic leukemia.