CASP8 and B-cell chronic lymphocytic leukemia: While pan-caspase- or caspase-8 inhibition had very little or no effect on the cytotoxicity induced by 3AC (Fig. 6a, b), necroptosis inhibition by NEC1s (inhibiting RIP1) or GSK-843 (inhibiting RIP3) did significantly reduce the 3AC-mediated cytotoxicity in primary CLL (Fig. 6c, d).