To determine whether recurrent loss-of-function mutations in the SHIP1-encoding INPP5D gene also exist in CLL, we next identified the types and frequency of INPP5D alterations in CLL in publically available sequencing data40–42 (using the cBioportal for Cancer Genomics platform (http://cbioportal.org)) and compared them to INPP5D mutations previously found to reduce SHIP1 phosphatase activity29 or protein stability43. The gene discussed is INPP5D; the disease is B-cell chronic lymphocytic leukemia.