Consistent with these data, when taking all breast cancer subtypes together MRC2 expression strongly correlates with a fibroblast TGFβ response signature (F-TBRS) (Fig. 1g), that serves as marker of fibroblast activation in the tumour stroma and is prognostic of poor outcome in colorectal cancers32,35. This evidence concerns the gene TGFB1 and neoplasm.