The cell type specificity of this receptor was confirmed by RT-qPCR analysis of cell populations sorted from dissociated mouse mammary tumours, demonstrating that Mrc2 (Endo180) expression is restricted to the PDGFRα-positive CAF population with no detectable expression on macrophages or other immune cells, endothelial cells, or tumour cells (Fig. 1b and Supplementary Fig. 1b). This evidence concerns the gene PDGFRA and breast cancer.