Moreover, while 4T1 and D2A1 tumour cells grow better on a CAF-derived ECM compared to a 3T3 fibroblast-derived ECM, there is again no difference in tumour cell proliferation (Fig. 3f and Supplementary Fig. 5d) or tumour cell colony formation (Fig. 3g) on matrices derived from Endo180 wildtype or Endo180-deficient CAFs. The gene discussed is MRC2; the disease is neoplasm.