Comparison of normal skin fibroblasts and CAFs in the mouse melanoma dataset33 and of normal tissue fibroblasts and tumour-associated fibroblast clusters in a human lung cancer single cell RNA-Seq dataset36 confirms upregulated Mrc2/MRC2 expression in subsets of CAFs (Supplementary Fig. 1e, f). The gene discussed is MRC2; the disease is neoplasm.