Tumour take was only observed in four out of nine Endo180−/− mice and, again, the tumours which do develop in the Endo180−/− mice grow more slowly than in wildtype mice such that at the termination of the experiment, there is a significant difference in tumour volume (Fig. 2c) and tumour weight (Supplementary Fig. 2a). The gene discussed is MRC2; the disease is neoplasm.