AKT1 and bacterial infectious disease: Moreover, the importance of Rac-GTP in phagocyte function is illustrated by a human immunodeficiency syndrome characterized by severe bacterial infections that arise from a mutation in the gene encoding Rac2 that generates the D57N substitution of Rac2 (Rac2D57N), which results in constitutive binding of GDP, accompanied by impaired ROS production, in phagocytes56,57.