RHBDF2 and Alzheimer disease: Another noteworthy gene is RHBDF2, where five Bonferroni significant DMPs in the temporal gyrus were annotated to (cg05810363: ES = 0.029, P = 2.25 × 10−11; cg13076843: ES = 0.031, P = 2.97 × 10−11; cg09123026: ES = 0.012, P = 3.46 × 10−9; cg12163800: ES = 0.025, P = 5.85 × 10−9; cg12309456: ES = 0.016, P = 1.33 ×10−8); and which has been highlighted in previous EWAS in AD in the individual cohorts5,6,12.