This included 15 novel genes with at least two Bonferroni significant DMPs each, including five probes in AGAP2, three probes in SLC44A2 and two probes each in CDH9, CPEB4, DUSP27, GCNT2, MAMSTR, PTK6, RGMA, RHOB, SMURF1, THBS1, ZNF238 and ZNF385A. These genes had not been identified previously in an AD EWAS at this significance threshold, although a number of these genes had been previously identified from DMR analyses, which have a less stringent threshold. This evidence concerns the gene PTK6 and Alzheimer disease.