Furthermore, increased infiltration of CD8+ T cells in tumors has been reported to be associated with better immunotherapy response in HCC.3 To investigate the effect of ICB in NASH-HCC, Pfister et al.1 first examined the T cells composition across three NASH mice models (CD-HFD, WD-HFD, and hURI-tetOFFhep) and one normal diet control with single-cell RNA-sequencing (scRNA-seq), flow cytometry, and mass spectrometry. The gene discussed is CD8A; the disease is metabolic dysfunction-associated steatohepatitis.