IPF progression mRNAs are involved in some IPF-related pathways, including “PI3K/Akt signaling” and immune system such as “B cell receptor signaling pathway”, “Chemokine signaling pathway” and “Jak-STAT signaling pathway” (FDR < 0.05, Hypergeometric test, Supplementary Fig. S2H). The gene discussed is AKT1; the disease is idiopathic pulmonary fibrosis.