In early-stage IPF co-expression network, mRNAs S100A8 (r = 0.85, P = 6.99E-3, Pearson correlation test) and TLR7 (r = 0.89, P = 3.01E-3, Pearson correlation test) that co-expressed with CTD-2528L19.6 have been reported to be novel biomarkers of IPF fibrosis31,32. This evidence concerns the gene S100A8 and idiopathic pulmonary fibrosis.