CXCR4 and neoplasm: The first category includes strategies targeting TAM recruitment and survival, such as blocking the CCL2-CCR2 axis thereby preventing monocyte mobilisation from the bone marrow and recruitment into inflammatory sites, or blocking the CSF1-CSF1R axis thereby inducing apoptosis of TAMs, or blocking the CXCL12-CXCR4 and angiopoietin 2 (ANG2)-TIE2 axes thereby depleting TIE2+ macrophages that are critical for tumor angiogenesis26,54.