Of note, phenelzine is a non-selective irreversible MAOI that inhibits both MAO-A and its isoenzyme MAO-B31; however, because mouse macrophages predominantly express MAO-A over MAO-B, phenelzine treatment mainly regulates TAM reprogramming via inhibiting MAO-A in these tumor models (Supplementary Fig. 5a). This evidence concerns the gene MAOA and neoplasm.