Importantly, similar CXCR5-negative cells, termed peripheral T helper (Tph) cells have also been described in the joints of sero-positive rheumatoid arthritis patients, where their presence is inversely correlated with a better disease prognosis.5 It is unclear how these tumor-associated Tfh-like cells and Tph cells are related to bona fide SLO-resident Tfh cells. This evidence concerns the gene CXCR5 and neoplasm.