While the starting CD8+T cell population from two myeloma patients (MM305, MM306) prior transduction was mainly composed of naïve, effector memory (CD45RA-CCR7-) and effector (CD45RA+CCR7-) phenotype, the phenotype following transduction with TCR control vector showed a dominant effector memory and a low percentage (6% and 15%) of CD45RA+CD62L+ (naive). The gene discussed is CCR7; the disease is plasma cell myeloma.