TIGIT and plasma cell myeloma: Consistently, T cell dysfunction in patients with MM14 has been recently attributed, among other factors, to high TIGIT expression.47 49 Accordingly, TIGIT blockade could restore anti-myeloma T-cell function.47 In the present study, we could confirm the senescent phenotype and high expression of TIGIT in T cells from newly diagnosed MM patients and further revealed a reduced expression of Δ133p53α.