Although an IL-6 monoclonal antibody shows minimal effect as monotherapy in hormone therapy-resistant metastatic prostate cancer [85], clinical trials of other drugs targeting IL-6 in metastatic breast cancer (NCT03135171) and metastatic pancreatic cancer (NCT04191421 and NCT04581343) are underway to determine the effect of IL-6 signaling inhibition on metastatic cancers. This evidence concerns the gene IL6 and metastatic malignant neoplasm.