CXCR3 is a key molecule in the interaction of breast cancer cells and MAFs, and the systemic administration of AMG-487, a CXCR3 antagonist, significantly suppresses pulmonary metastatic colonization in both immunodeficient and immunocompetent mice, which suggests that the antimetastatic activity of AMG-487 is mediated at least partially by the blockade of the activation of MAFs [20]. Here, CXCR3 is linked to breast carcinoma.