PIK3CA and angioosteohypertrophic syndrome: In this study, we analysed for the presence of a PIK3CA mutation in a large cohort of lymphatic malformations, including common LM, lymphatico-venous malformation (LVM), capillaro-lymphatic malformation (CLM), capillaro-lymphatico-venous malformation (CLVM), unilateral capillaro-lymphatico-venous malformation with hypertrophy (KTS), CLOVES syndrome, unclassified PROS and unclassified vascular anomaly syndrome (UVA).