PIK3CA and lymphangioma: To assess the contribution of PIK3CA mutations in common, combined and syndromic LM (Table 1), we screened DNA extracted from frozen tissues or isolated cells from 143 patients: 105 common LM, 3 LVM, 1 CLM, 7 CLVM, 4 KTS, 14 CLOVES, 7 PROS and 2 UVA.