Even though Girk2 mutations have not been identified in human cases of PD so far, the model exhibits many significant hallmarks of the disease, such as neuroinflammation [13–15], oxidative stress [13, 16, 17], dopamine reduction in the striatum [15, 18], motor deficits [15, 18, 19], a-synuclein pathology [17], reduced levels of BDNF [13, 15], and cognitive impairment in the more progressed stages of degeneration [19]. The gene discussed is BDNF; the disease is Parkinson disease.