ACE2 and bacterial infectious disease with sepsis: We found low renal ACE2 mRNA levels in both COVID-19 (fold change 0.42, p = 0.0002) and bacterial sepsis patients (fold change 0.24, p < 0.0001) compared to control, whereas the mRNA levels of CD147 remained unaltered in renal tissue from COVID-19 and bacterial sepsis patients compared to control (Fig. 3).