Zou et al. [131] injected UC-MSCs-MVs via the caudal vein after IRI, and the results showed that hu-MSCs decreased Scr, BUN, apoptosis, HIF-1α, α-SMA, and renal fibrosis and increased Ki67, VEGF, PHD2, and VHL. Here, ACTA1 is linked to renal fibrosis.