Rodrigues et al. [134] injected hu-MSCs via vein injection in an IRI rat model, and the results showed that hu-MSCs could decrease BUN, Scr, FENa, TGF-β1, HO-1, miR-29a, miR-34a, and renal fibrosis, but miR-29b and miR-335 were not changed. This evidence concerns the gene HMOX1 and renal fibrosis.