HMOX1 and renal fibrosis: Du et al [119] also assessed the effects of WJ-MSCs on acute and chronic kidney injury induced by IRI and reported that WJ-MSCs inhibited Scr, BUN, collagen, α-SMA, renal fibrosis, and renal tubular cell apoptosis and increased p-Akt, HGF, HO-1, IL-10, and renal tubular cell proliferation.