In the current study, the binding of p-STAT1 to the enhancers of TNFAIP2 and LCP2 was significantly increased in tissues from mice with chronic colitis, suggesting that both p-STAT1 deposition and H3K27ac enrichment occur on the same enhancer of both the TNFAIP2 and LCP2 genes. This evidence concerns the gene STAT1 and Chronic colitis.