Besides, the S1P gene is highly expressed in many cancer cells, such as colon cancer cells, where a high concentration of S1P are released to act on lymphatic endothelial cells and immune cells in the tumor microenvironment, induce lymphatic generation and metastasis and promote the invasion and lymphatic metastasis of colorectal cancer [126, 127]. The gene discussed is MBTPS1; the disease is neoplasm.