IGF2BP3 and central nervous system cancer: For example, circHIPK3 can bind to multiple miRNAs, including miR-654 and miR-124-3p, and several studies have demonstrated that circHIPK3 targets miR-654, which targets insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3), suggesting that circHIPK3 promotes glioma progression by regulating the miR-654/IGF2BP3 axis [15].