The results of in vitro experiment revealed that the LINC00963/miR-320a axis regulated the processes of ER stress, apoptosis and autophagy in DLBCL cells, while in vivo experiment showed that the progression of DLBCL could be suppressed by the induction of LINC00963 overexpression. Here, LINC00963 is linked to diffuse large B-cell lymphoma.