Our previous study indicated that HBx hijacks WDR5 to promote target oncogenes’ promoter H3K4me3 modification [6], which suggests that the increased ALKBH5 expression in HBV-HCC might be mediated through the HBx-WDR5-H3K4me3 axis. The gene discussed is ALKBH5; the disease is hepatocellular carcinoma.