However, in our present study, including total 99 cases of clinical samples and combining with further data by mining the database from two cohorts of 159 Fudan Chinese HBV-HCC and 115 TCGA HBV-HCC patients [24, 27], we confirmed that ALKBH5 is up-regulated in most HBV-HCC tissues and predicts a poor prognosis. The gene discussed is ALKBH5; the disease is hepatocellular carcinoma.