ALKBH5 and hepatocellular carcinoma: We further data mined 159 Fudan HBV-HCC cohort to analyze the correlation between WDR5 and ALKBH5 expression, we found that WDR5 was indeed increased in the HBV-HCC at both mRNA and protein level (Fig. 4C) and the increased WDR5 level predicted a poor prognosis in accordance with previous reports [6] (Fig. 4D, Left panel).