In this network, GPC3 exhibited significant correlation with SERPINA1, MFI2, and FOXM1 directly in the PPI network, indicating that GPC3 might also act in NSCLC by interacting with SERPINA1, MFI2, and FOXM1. Germline mutation of MFI2 is significantly greater in LUAD patients among young non-smokers, which may be implicated in the pathogenesis of LUAD [46]. The gene discussed is SERPINA1; the disease is non-small cell lung carcinoma.