As shown in Table 1, Fig. 4a and b, we obtained 8 genes related to the HCC prognosis (p-value < 0.1), among which CENPA, CDCA8, EZH2, KIF20A, and KPNA2 acted as hazardous factors (HR > 1), and CCNB1, KIF18B and MCM4 were protective factors (HR < 1). The gene discussed is MCM4; the disease is hepatocellular carcinoma.