Our study is the first application of these eight BIRC5-related genes to predict the prognosis and clinical treatment significance of HCC patients, as well as this study still has various limitations and requires further optimization, so further fundamental experiments and pre-clinical trials are needed to uncover the molecular mechanism of the eight genes in HCC progression, and the predictive efficiency of this signature needs to be measured before clinical application. This evidence concerns the gene BIRC5 and hepatocellular carcinoma.