NLRP1 and migraine disorder: For instance, a recent genome-wide association analysis (GWAS) that compared genetic data of 59,674 migraine cases and 316,078 control individuals yielded 38 genomic susceptibility loci in human, among which 5 genes, i.e. TSPAN2, MEF2D, NLRP1, JAM3 and NOTCH4, that are associated with inflammation [78].