Phenotypic screens were performed in the human osteosarcoma cell line U2OS, which recapitulates the PI3K/AKT-mediated inactivation of FOXO3a by cystosolic sequestration (Brunet et al., 2002; Cautain et al., 2016; Link et al., 2009; Zanella et al., 2008). The gene discussed is AKT1; the disease is osteosarcoma.