Our behavioral study indicated that stimulating exogenous and endogenous IL‐10 expression have displayed marked pain anti‐hypersensitive activity in animal models of neuropathic pain, peripheral diabetic pain, bone cancer pain, and complete Freund's adjuvant (CFA)‐induced inflammatory pain.23, 24, 25, 26, 27, 28. This evidence concerns the gene IL10 and bone cancer.