TNF and brain disorder: The coordinative activity of microglia and neurons in brain diseases has been intensively studied,7, 8, 9 while microglial‐derived factors sensitize sensory processing through tumor necrosis factor (TNF)‐α, IL‐6, IL‐1β, and P2X inotropic receptors and leading to restore spinally mediated nocifensive reflexes mediated proinflammatory cytokines.10, 11, 12, 13