VEGFA and retinal degeneration: Functional analyses reveal that RRPPR fused to an optimized domain of Cav (CVX51401) is more potent than AP-Cav at inhibiting vascular endothelial growth factor-A (VEGF) induced nitric oxide (NO) release in ECs, VEGF initiated vascular permeability in vivo and retinal degeneration in an immunological model of uveitis in mice.