KDM4A and disease arising from reactivation of latent virus: Since currently knowledge provide evidence shows that in addition to latent infection, herpesvirus lytic infected cell may also participate in tumorigenesis through an abortive lytic phase that express lytic genes with the potential to cause cancer [20], we have used KSHV reactivation as a model and identified KDM4A as a cancer-associated epigenetic regulator [11,12].