DNMT3A and Huntington disease: Like in the brain samples of HD patients, we observed a robust downregulation of DNMT3A (Z-ratios: - 1.24, -1.79, - 1.14) in the striatum of R6/2 and YAC128 mice and the mice could be discriminated based on DNMT3A levels (AUC = 0.83; 95% CI = [0.66, 0.99]).