Analysis of the target genes of the top five TFEA hits, the mitochondrial transcription termination factor 3 (MTERF3), Myb/SANT DNA binding domain containing 4 with coiled-coils (MSANTD4), small nuclear RNA activating complex polypeptide 5 (SNPAC5), zinc finger protein 833 (ZNF833), and thymocyte nuclear protein 1 (THYN1), showed that most of their target genes were upregulated in the brain of HD patients (Fig 4 and S6 File). The gene discussed is MSANTD4; the disease is Huntington disease.