In contrast, HMGN3 was only highlighted by TFEA of the M1 module, correlating with HD in the brain, and not in the blood datasets which may imply that dysregulation of HMGN3 may be confined to the brain In R6/2 and YAC128 mice, HMGN3 mRNA levels were elevated (Z-ratios: 1.89, 0.78, 2.06) in HD mice and control and HD mice could be well discriminated based on the HMGN3 mRNA levels. The gene discussed is HMGN3; the disease is Huntington disease.