Besides the interaction of CIP4/TRIP10 with HTT and CDC42, CIP4/TRIP10 can interact with the vesicle-associated membrane protein 2 (VAMP2) and 7 (VAMP7) which are linked with other genes robustly altered in the brain of HD patients such as the vesicle-associated membrane protein 1 (VAMP1) and the Ras-related Protein Rab-14 (RAB14) [35]. This evidence concerns the gene CDC42 and Huntington disease.