PAK3 and Huntington disease: While PAK2 was not robustly altered in the brain of HD patients (Z-ratios: -1.43; 1.31; 0.7), PAK3 mRNA levels (Z-ratios: 1.98; 0.46; 0.70) were slightly elevated in the brain of HD patients, although it was not identified by RRA (p = 0.10).