Alongside with the mRNA levels of their target genes, mRNA levels of the distal-less homeobox 1 (DLX1) (regulates 11.9% of M1, TFEA rank = 6, Z-ratios: 2.21; 0.16; 1.04), protein arginine methyltransferase 3 (PRMT3) (regulates 11.6% of M1, TFEA rank = 14, Z-ratios: 0.46; 2.65; 1.11), and nuclear transcription factor Y subunit β (NFYB) (regulates 29.7% of M1, TFEA rank = 24, Z-ratios: 1.05; 2.39; 2.02) were robustly upregulated in the brain of HD patients (Fig 4 and S6 File). The gene discussed is TFE3; the disease is Huntington disease.