ACTR6 and Huntington disease: Further indicating that transcriptional dysregulation of regulators of the actin cytoskeleton may be important in HD, other actin-related proteins such as ACTR3B (Z-ratios: 1.3; 1.30; 1.62), ACTR6 (1.38; 1.54; 1.88) and ACTR10 (Z-ratios: 1.64; 1.23; 1.34) were robustly upregulated in the blood of HD patients according to this meta-analysis.