Furthermore, although the effects of the P2X7 receptor are manifested in transducing danger signals and regulating neurochemistry under stress [19] and it has been hypothesised that P2RX7 predisposes to depression in interaction with life stress [26], studies investigating the role of variation in P2RX7 in depression have not considered the effects of stress. The gene discussed is P2RX7; the disease is depressive disorder.