P2RX7 and major depressive disorder: This finding is in line not only with the supposed activation of P2RX7 by stress and danger signals, but also with findings in our previous study, where using a Bayesian network analysis approach we reported that none of several variants previously associated with depression in seven genes including rs758311 in P2RX7 showed relevance with respect to a complex depressive phenotype in the absence of stress, while the majority of them gained relevance in those exposed to moderate or severe recent life events [28].