Several clinical studies reported on the effect of intravitreal anti-VEGF in vitrectomized eyes, but these were only small case series (nAMD, 4 eyes), cohorts of patients with pathologies other than nAMD (macular edema due to diabetic retinopathy or retinal vein occlusion), or cases of patients who underwent core rather than total vitrectomy [18–23]. Here, VEGFA is linked to macular retinal edema.