Accordingly, examination of public functional genomics data revealed that the Runx1-bound Zeb1 enhancer we identified in mK4 cells is accessible (i.e., DNase hypersensitive) in other tissues including several hemopoietic cell lines (S4 Table) and is also bound by Runx1 in AML. The gene discussed is RUNX1; the disease is acute myeloid leukemia.