Since enrichment analysis found significant enrichment for our mK4 Runx1 ChIP sites in AML (10.73 fold enriched, p-value 8.42 x 10−168) and HPC-7 cells (9.73 fold enriched, p-value 1.13 x 10−143; S4 Table), these may be functionally important Runx1-dependent enhancers in multiple cellular contexts. The gene discussed is RUNX1; the disease is acute myeloid leukemia.