HSPA5 and COVID-19: 2020). It has been reported that some natural products such as TQ have high to a moderate binding affinity to the heat Shock Protein A5 (HSPA5) substrate-binding domain β (SBDβ), which reported to be the recognition site for the SARS-CoV-2 spike. This natural compound may be used to reduce the risk of COVID-19 or possibly to treat the disease, especially in high-risk people (Elfiky 2020).