Yang et al.54 have proposed that the spanning junction ORF in circ-FBXW7 driven by IRES encodes a novel 21-kDa protein, termed FBXW7-185aa, which decreases the half-life of c-Myc by antagonizing USP28-induced c-Myc stabilization, and inhibits proliferation and progression in glioblastoma. This evidence concerns the gene MYC and glioblastoma.