In a meta‐analysis performed by Jelleyman et al. (2015), the authors identified a significant reduction in insulin resistance following HIIT (standardized mean difference of −0.33 95%CI [−0.47 ‐ −0.18]), although these data are not exclusively from studies investigating samples of participants living with obesity and SIT (Jelleyman et al., 2015). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.