Indeed, circulating levels of several inflammatory cytokines (i.e., CRP, IL‐1β, IL‐6, IL‐8, MCP‐1, and TNFα) have been shown to be increased in obesity (Lacasa et al., 2007; O’Hara et al., 2012). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.