Macrophages are an important contributor to obesity‐associated inflammation (Curat et al., 2006; O’Hara et al., 2012), and the cross‐talk between macrophages and adipocytes/preadipocytes may play a key role in the progression of obesity‐associated central arterial stiffness, particularly in the context of MMP‐3‐associated ECM remodeling (O’Hara et al., 2009, 2012). The gene discussed is MMP3; the disease is obesity due to melanocortin 4 receptor deficiency.