Previous studies, but not all (Maquoi et al., 2003; Wu et al., 2017), that have examined the association between MMP‐3 and obesity have found MMP‐3 to be upregulated in mice with nutritionally induced (Maquoi et al., 2002) and genetic obesity (i.e., ob/ob and db/db mice) (Chavey et al., 2003; Unoki et al., 2006). This evidence concerns the gene MMP3 and obesity due to melanocortin 4 receptor deficiency.