In different mouse models, a direct inhibitory effect of exercise on tumor growth was found (Pedersen et al., 2016), where the exercise‐induced release of epinephrine and interleukin (IL)‐6 into the bloodstream resulted in mobilization, redistribution, and activation of NK cells, with increased infiltration of activated NK cells (Pedersen et al., 2016). This evidence concerns the gene IL6 and neoplasm.