PDCD1 and colorectal carcinoma: In 2015, Le et al. showed that pembrolizumab, a programmed cell death protein 1 (PD1) inhibitor, had a different activity in CRC based on MMR status; the immune-related objective response rate (ORR) was 40%, and progression-free survival (PFS) rate was 78% in MSI-H-dMMR CRC and 0% and 11% respectively for MSI-L/MSS-pMMR CRC [5].