Another phase Ib/II trial (NCT02713529) will assess the combination of pembrolizumab with AMG 820, an antibody targeting colony-stimulating factor 1 receptor (CSF-1R) that regulates TAMs recruitment and survival; preliminary data of this study have reported only 4.9% ORR in pMMR CRC patients’ cohort (Table 1). Here, CSF1R is linked to colorectal carcinoma.