CMS2 subtype includes 35% of CRC and is characterized by chromosomal instability (CIN) and upregulation of WNT and MYC pathways: This subtype might be defined as an “immune-excluded tumor.” The same might be said for CMS3 subtype, characterized by a high rate of K-RAS mutations and usually defined as the metabolic subgroup [21]. Here, KRAS is linked to neoplasm.