CD8A and colorectal carcinoma: In preclinical murine models, a suppressive activity on CCL4 gene transcription by WNT/β-catenin pathway, commonly upregulated in CMS2/pMMR CRC tumors, was observed, leading to low levels of CCL4 chemokine and impaired CD103+ dendritic cells (DCs) and CD8+ T cell infiltration and subsequent activation in TME [23, 24].