PDCD1 and colorectal carcinoma: Focusing on RAF/MEK axis, the combination of encorafenib + binimetinib + nivolumab and dabrafenib + trametinib + spartalizumab, an anti-PD1 drug, in patients affected by BRAF-V600E mutated pMMR CRC is being evaluated in phase I/II NCT04044430 and phase II NCT03668431 trials respectively.