CHGA and Ascites: Univariate regression analysis also demonstrated high metastatic liver burden of > 50% liver volume (hazard ratio HR 2.6, 95% CI 1.05–6.61; p = 0.04), five or greater skeletal metastatic deposits (HR 2.72, 95% CI 1.07–6.88; p = 0.035), high level of baseline chromogranin A of ≥ 4 × ULN (HR 4.34, 95% CI 1.76–10.7; p = 0.001), pre-existing ascites (HR 4.51, 95% CI 1.3–15.59; p = 0.017), development of interim ascites (HR 2.64, 95% CI 1.09–6.38; p = 0.032) and non-GEP-NETs (HR 3.07, 95% CI 1.24–7.6; p = 0.016) to be risk factors of poor OS (Table 3).