CHGA and Ascites: In addition, we found that OS was inversely related to elevated chromogranin A of ≥ 4 × ULN (33.9 months vs. not reached; p < 0.001), pre-existing ascites (11.1 months vs. not reached; p = 0.009), development of interim ascites (43.2 months vs. not reached; p = 0.026) and non-GEP-NETs (37.5 months vs. not reached; p = 0.011) (Table 2; Figs. 1 and 2).