HLA-C and infectious disease: The second assumption, that MHC variants differ in their repertoire of presented peptides, is empirically well supported (Sidney et al. 2008; Schellens et al. 2015; Pierini and Lenz 2018) and so is the fact that different MHC variants are associated with different infectious diseases (Trowsdale 2011; Tian et al. 2017; Sanchez-Mazas 2020).