HLA-B and AIDS: Recently, Arora et al. (2019) showed that the protective effect of HLA-B alleles against HIV-1 viral load is positively correlated with the number of HIV-1 peptides that a given HLA variant is predicted to bind, an effect that was also observable at the genotype level where HIV-1-infected individuals whose HLA-B variants together were predicted to bind more HIV-1 peptides also exhibited a lower viral load and thus a slower progression toward AIDS (Arora et al. 2020).