PRRT2 and helminthiasis: Despite the fact that PKC-θ is required for TCR-induced T-cell activation in vitro (Pfeifhofer et al., 2003; Sun et al., 2000), PKC-θ deficiency has a different impact on immune responses against in vivo bacterial (Sakowicz-Burkiewicz et al., 2008), viral (Berg-Brown et al., 2004; Giannoni et al., 2005; Marsland et al., 2005; Marsland et al., 2004) and helminth infections or model allergens (Marsland et al., 2004; Salek-Ardakani et al., 2005).