After intravenous injection of paclitaxel albumin nanoparticles, the drug concentration in the liver and kidney was relatively high, and the drug concentration decreased rapidly in various tissues of the mice, and the same trend was also observed in the tumor site, indicating that the time of the anti-tumor action of paclitaxel albumin nanoparticles was shortened after it entered the body. This evidence concerns the gene ALB and neoplasm.