Excreted mostly unchanged in urine.Not affected by CYP inhibitors or inducers.Limited incidence of decreased hemoglobin, increased LDL, HDL, creatinine, creatine phosphokinase.Renal secretion affected by probenecid.No association with QT prolongation.Potential risk of gastrointestinal perforation in patients with intestinal diverticulum/diverticulitis. This evidence concerns the gene PPIG and Colonic diverticula.