ACLY and ACSS2 are both regulated by SREBP transcription factors, and expression of each is elevated in numerous cancer types (Hatzivassiliou et al. 2005, Comerford et al. 2014, Mashimo et al. 2014, Schug et al. 2015, Carrer et al. 2019). This evidence concerns the gene ACSS2 and cancer.