CRP and cardiovascular disorder: First, CRP is related to the dysfunction of endothelial cells and the progression of atherosclerosis, it has a direct proinflammatory effect by inducing a significant increment of adhesion molecule expression in human endothelial cells and decreasing the synthesis of nitric oxide as well as release of prostacyclin produced by endothelial cells which will facilitate the development of diverse cardiovascular diseases (33–35).