TNFSF10 and cancer: Although other biological activities were also described for ONC201 and its congeners, e.g., dopamine D2 receptor antagonism or upregulation of the endogenous TNF-related apoptosis-inducing ligand (TRAIL) (Allen et al., 2015; Kline et al., 2018), a recent meta-analysis across 539 human cancer cell lines identified ClpP as the most significant biomarker for imipridone susceptibility of eukaryotic cells (Bonner et al., 2020).