Although other biological activities were also described for ONC201 and its congeners, e.g., dopamine D2 receptor antagonism or upregulation of the endogenous TNF-related apoptosis-inducing ligand (TRAIL) (Allen et al., 2015; Kline et al., 2018), a recent meta-analysis across 539 human cancer cell lines identified ClpP as the most significant biomarker for imipridone susceptibility of eukaryotic cells (Bonner et al., 2020). This evidence concerns the gene CLPP and cancer.