We detected the mRNA expression of ZEB1 in bone tissue from postmenopausal osteoporosis (PMOP) patients, and results showed that in PMOP patients, the expression of osteogenesis genes such as osterix, RUNX2, and Col1a1 in bone tissue was positively related with BMD, while ZEB1 expression was negatively related with osteogenesis genes and BMD (Figure 1). This evidence concerns the gene COL1A1 and postmenopausal osteoporosis.