With regard to the molecular mechanism associated with lung fibrosis, several studies reported that gal3 was one of the most up-regulated genes collaborated with fibrotic marker TREM2 and SPP1 in a subset of pro-fibrogenic macrophages (Krasemann et al., 2017; Ramachandran et al., 2019; Zhou et al., 2020). This evidence concerns the gene LGALS3 and pulmonary fibrosis.