Gal-3, a glycan-recognizing protein mainly found in the cytoplasm and cell membrane, participates in a wide range of cellular signaling processes and regulates biological events such as inflammation, cancer, cell proliferation, cell cycle and apoptosis (Gonnermann et al., 2020; Schroeder et al., 2020; Song et al., 2020). The gene discussed is LGALS3; the disease is cancer.